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Toronto, Nov 8 (PTI) People who receive the Pfizer or AstraZeneca COVID-19 vaccine have antibody levels significantly higher than those infected with the SARS-CoV-2 virus, according to a study published in Scientific Reports journal on Monday.<\/p>\n
A team led by researchers at the University of Montreal in Canada found that these antibodies were also effective against the Delta variant.<\/p>\n
In the study, 32 non-hospitalised COVID-19 positive Canadian adults were recruited 14 to 21 days after being diagnosed through PCR testing in 2020, before the Beta, Delta and Gamma variants emerged.<\/p>\n
“Everyone who had been infected produced antibodies, but older people produced more than adults under 50 years of age,” said Jean-Francois Masson, a professor at the University of Montreal.<\/p>\n
“In addition, antibodies were still present in their bloodstream 16 weeks after their diagnosis,” Masson said.<\/p>\n
Antibodies produced after an infection by the original viral strain also reacted to SARS-CoV-2 variants that emerged in subsequent waves, namely Beta, Delta and Gamma, with a reduction of 30 to 50 per cent in reactivity.<\/p>\n
“But the result that surprised us the most was that antibodies produced by naturally infected individuals 50 and older provided a greater degree of protection than adults below 50,” said Joelle Pelletier, a professor at the University of Montreal.<\/p>\n
“This was determined by measuring the antibodies’ capacity to inhibit the interaction of the Delta variant’s spike protein with the ACE-2 receptor in human cells, which is how we become infected,” he added.<\/p>\n
The researchers, however, did not observe the same phenomenon with the other variants.<\/p>\n
They noted that when someone who has had a mild case of COVID is vaccinated, the antibody level in their blood doubles compared to an unvaccinated person who has been infected by the virus.<\/p>\n
Their antibodies are also better able to prevent spike-ACE-2 interaction, according to the researchers.<\/p>\n
“But what’s even more interesting is that we have samples from an individual younger than 49 whose infection didn’t produce antibodies inhibiting spike-ACE-2 interaction, unlike vaccination,” said Masson.<\/p>\n
“This suggests that vaccination increases protection against the Delta variant among people previously infected by the native strain,” Masson added.<\/p>\n
The researchers believe more research should be conducted to determine the best combination for maintaining the most effective level of antibodies reactive to all variants of the virus.<\/p>\n
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