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Guwahati, Sep 26 (PTI) Researchers at IIT-Guwahati have developed a new strategy to deliver chemotherapeutic drugs directly to the infected cells of a cancer patient, thereby significantly reducing side effects.<\/p>\n
Explaining it, professor Debasis Manna of the Department of Chemistry said the researchers had two needs in the development of chemotherapy drugs — it must be targeted at the cancer cells and must be released by an external trigger whenever it is required.<\/p>\n
“The problem with existing chemotherapeutic drugs is that they kill healthy cells of the body in addition to cancerous cells, leading to numerous undesirable side effects,” IIT-Guwahati said in a statement on Monday.<\/p>\n
In fact, it is believed that cancer deaths are as much due to the side effects of chemotherapy as the disease itself, it added.<\/p>\n
“There is worldwide research to overcome the drawbacks of secondary toxicity of chemotherapeutic drugs. Some strategies that are being explored include target-specific delivery of the drugs and on-demand delivery of appropriate drug doses to cancerous cells and tissues,” it said.<\/p>\n
The molecules developed by the IIT-Guwahati researchers self-assemble as capsules to hold the drug, which then attaches only to cancer cells, the statement said.<\/p>\n
“When infrared light is shone on it, the shell breaks and releases the encapsulated drug into the cancerous cell. The IIT-G scientists rightly believe that their approach would allow the development of drug carriers for chemotherapy with enhanced efficacy and negligible side effects,” it added.<\/p>\n
The research papers have been co-authored by Manna, along with his research scholars Subhasis Dey, Anjali Patel, and Biswa Mohan Prusty among others.<\/p>\n
Anti-cancer activities were carried out in collaboration with professors Siddhartha Sankar Ghosh and Plaboni Sen of IIT-Guwahati, and professors Arindam Bhattacharyya and Soumya Chatterjee of Calcutta University.<\/p>\n
“The path-breaking results of this research have been published in prestigious journals of The Royal Society of Chemistry, including ‘Chemical Communications’ and ‘Organic and Biomolecular Chemistry’,” the statement said.<\/p>\n
The premier technical institute said that the societal impacts of this work cannot be overstated given the number of cancer patients in India anticipated to be 30 million by 2025.<\/p>\n
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Guwahati, Sep 26 (PTI) Researchers at IIT-Guwahati have developed a new strategy to deliver chemotherapeutic drugs directly to the infected cells of a cancer patient, thereby significantly reducing side effects. Explaining it, professor Debasis Manna of the Department of Chemistry said the researchers had two needs in the development of chemotherapy drugs — it must […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":{"0":"post-201401","1":"post","2":"type-post","3":"status-publish","4":"format-standard","6":"category-north-east"},"_links":{"self":[{"href":"https:\/\/arunachaltimes.in\/index.php\/wp-json\/wp\/v2\/posts\/201401","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arunachaltimes.in\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arunachaltimes.in\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arunachaltimes.in\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/arunachaltimes.in\/index.php\/wp-json\/wp\/v2\/comments?post=201401"}],"version-history":[{"count":0,"href":"https:\/\/arunachaltimes.in\/index.php\/wp-json\/wp\/v2\/posts\/201401\/revisions"}],"wp:attachment":[{"href":"https:\/\/arunachaltimes.in\/index.php\/wp-json\/wp\/v2\/media?parent=201401"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arunachaltimes.in\/index.php\/wp-json\/wp\/v2\/categories?post=201401"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arunachaltimes.in\/index.php\/wp-json\/wp\/v2\/tags?post=201401"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}